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Oral: between 80% to 90% of the oral dose is lost through the liver and create undesirable metabolites, unnecessarily burdening your liver.
Suppositories: bypass liver, however, create sharp spikes in progesterone levels
Sublingual: also, create sharp spikes
Injections: normally progestin, the synthetic version; also sharp spikes; unpleasant protocol
Topical: A proper cream formula is superior, as it will deliver 98-100% of the progesterone into circulation, yielding stable levels for approximately 12 hours
A properly formulated bio-identical progesterone cream has 40+ years of Safety & effectiveness.